The drug maker manipulated the publication of studies to bolster use of its epilepsy drug neurontin, according to expert witnesses in a lawsuit against the company. Further work is required to expand the number of enzymes that could be exploited to direct. Expert opinion on drug discovery abbreviation issn. Discovery of a novel, firstinclass, orally bioavailable. Expert opinion instructions for authors submitting to the expert collection. Expert opinion on drug discovery 2016, 11 10, 10011016. Discovery and development of varenicline for smoking cessation. Raman spectroscopy has a number of potential applications within drug discovery and development. Since its discovery, other molecules that mimic its mechanism of action have been developed, commencing a new age in the treatment of depression. Development of nobased therapeutics is and will continue to be a major focus of biotech and. While the oral route of delivering a drug remains the most convenient and common mode, one of the challenges of this method is the poor bioavailability of oral dosage.
Medical journals are published regularly to communicate new research to clinicians, medical scientists, and other healthcare workers. Download the list of journals included in this collection. Treatment of sars and mers in outbreak settings has focused on therapeutics with general antiviral activity and good safety profiles rather than efficacy data provided by cellular, rodent, or nonhuman primate models of highly pathogenic coronavirus infection. Recent developments suggest that, as well as determining preclinical admet absorption, distribution, metabolism, elimination and toxicology properties, compounds of optimal lipophilicity might have increased chances of success in development. Pages in category pharmacology journals the following 161 pages are in this category, out of 161 total. If you have problems viewing pdf files, download the latest version of adobe reader. Suggestions for further improvements are also discussed. Computational prediction of oral drug absorption based on. It can also be used in compatibility studies during the drug formulation process.
Pdf drug repurposing approaches to fight dengue virus. Broadspectrum coronavirus antiviral drug discovery. Expert opinion on drug discovery offprints and colour figure order form you are entitled to 10 free offprints of your paper not for distribution to information companies. Structural information on gpcrs will be more abundantly available for early stages of drug discovery projects, providing. You can also order 1 set of 100 at a discounted rate of. Classic antidepressants that modulate monoaminergic systems are not sufficiently effective and require long systematic application. Expert opinion on drug metabolism and toxicology 4, 545568.
Browse the list of issues and latest articles from expert opinion on drug discovery. Expert opinion on drug discovery 2019, 14 7, 619637. Learning from structurebased drug design and new antivirals targeting the ribonucleoprotein complex for the treatment of influenza. Pdf application of nitric oxide in drug discovery and development. How do we improve histone deacetylase inhibitor drug discovery. Recent advances in cns research and drug discovery are presented, especially with regard to assessment of relevant neuropk parameters. Expert opinion on drug discovery 2019 download pdf. After years of industrywide disinvestment from antibiotic research, a few large companies are reinvesting. Users can view or download content wherever they are. Expert opinion on drug discovery 2015, 10 4, 345371. It was originally called microbia, inc microbia was founded by postdocs from the lab of gerald fink at the whitehead institute to commercialize approaches that had been developed in the lab to improve industrial fermentation of fungi, to genetically engineer them to produce secondary metabolites more efficiently or to.
Accelerating drug discovery through tight integration of. The rationale for creating a 3rd mechanism for drug discovery which works linking biopharma with fundamental research is thoroughly compelling. National center for advancing translational sciences. Expert opinion 2020 print issn online issn volume url. Volume 15 2020 volume 14 2019 volume 2018 volume 12 2017 volume 11 2016 volume 10 2015 volume 9 2014 volume 8 20 volume 7 2012 volume 6 2011 volume 5. Expert opinion fluoxetine is the first selective ssri that has a recognised clinical efficacy and safety profile. There have been a number of highthroughput assays developed in recent years to meet the scaled up demands for compound profiling. Discovery and development of varenicline for smoking. Explore archive content from our portfolio of expert opinions in our modern archive package. Including address, academic qualifications and job titles of all authors, as well as telephone number and email address of the author for correspondence on a. Based on lessons learned from sars and mers outbreaks, lack of drugs. Investigation of the relationship between topology and. Pages in category pharmacology journal stubs the following 72 pages are in this category, out of 72 total.
All article types should have a concise, informative title that contains no brand names. Expert opinion on drug discovery 2019 promiscuity of in vitro secondary pharmacology assays and implications for lead optimization strategies dean g. Molecular mechanisms underlying chemical liver injury. Importance of solubility and lipophilicity in drug development.
Download hires image download to mspowerpoint cite this. Accelerating drug discovery through tight integration of expert molecular design and predictive scoring. Deuterated drugs collectively are worth at least a billion dollars. Article pdf available in expert opinion on drug discovery 56. It would seem that the likelihood of obviousness rejections is increasing in this area. Expert opinion with the recent progress in biophysical detection techniques the advantages of fragmentbased drug discovery could be exploited for gpcr targets. The flow cytometer is unique among biomedical analysis instruments because it makes simultaneous and multiple optical measurements on individual cells or particles at. How do we improve histone deacetylase inhibitor drug. This article lists academic journals that focus on the practice of medicine or any medical specialty. Mechanistic models enable the rational use of in vitro. The editorinchief david janero northeastern university abstracting and indexing. Recent studies suggest that substances that modulate glutamatergic system may produce an antidepressant.
The poor solubility of a compound can lead to reduced productivity in terms of drug discovery and development. The role of lipophilicity in determining the overall quality of candidate drug molecules is of paramount importance. Pdf expert opinion on drug discovery glutamatebased. All journal articles featured in expert opinion on drug discovery vol issue 1. All journal articles featured in expert opinion on drug discovery vol 15 issue 5. The journal is abstracted and indexed in chemical abstracts, embaseexcerpta medica, and science citation index expanded. Docking screens for dual inhibitors of disparate drug. Induced degradation by stateoftheart compounds proteolysistargeting chimeras, protacs has been shown for protein kinases, albeit in early preclinical stages.
These metrics are regularly updated to reflect usage leading up to the last few days. Expert opinion on drug discovery 2016 optimizing celgosivir therapy in mouse models of dengue virus infection of serotypes 1 and 2. Pdf maximizing computational tools for successful drug discovery. Molecular mechanisms underlying chemical liver injury volume 14 xinsheng gu, jose e. Influential journals include expert opinion on biological therapy, expert opinion on drug delivery, expert opinion on investigational drugs, and expert opinion on therapeutic targets. Expert opinion on drug discovery rg journal impact.
Drug discovery efforts are now involved with finding compounds that may affect known signaling pathways involved in hair growth, hf cycling and stem cell mobilization, differentiation and proliferation. Expert collection 2019 title list 2019 print issn online. Acronym title print issn online issn 2019 volume number url iebt expert opinion on biological therapy 14712598 17447682 19. Mechanism of action of cariprazine volume 21 issue 2 stephen m. The search for a window for potential therapeutic efficacy. Ironwood pharmaceuticals, inc is a publicly traded pharmaceutical company. Recent developments suggest that, as well as determining preclinical admet absorption, distribution, metabolism, elimination and toxicology properties, compounds of optimal lipophilicity might have increased chances of success in. It can be used to estimate the molecular activity of drugs and to establish a drug s physicochemical properties such as its partition coefficient. Pdf drug discovery is an iterative cycle of identifying promising hits followed by lead optimization via bioisosteric replacements. Article views are the countercompliant sum of full text article downloads since november 2008 both pdf and html across all institutions and individuals. However, careful elucidation of metabolic outcomes from deuteration that would not be anticipated from the prior art, and are instead unexpected and unobvious, has enabled. Expert opinion on drug discovery 2010 download pdf. Drug discovery today the magazine for the drug discovery.446 1390 26 549 506 231 1127 1453 430 617 1369 48 509 711 1224 676 575 1356 304 1150 426 440 278 459 1267 1546 1237 41 216 259 756 141 1001 1489 838 967 213 450 494 1074 1267 1229 936